Hyalo4 START Ointment 30g with Hyaluronic Acid

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Hyalo4 START is a fluid ointment made in Italy by Fidia Farmaceutici. It combines hyaluronic acid with bacterial collagenase and is used to prepare the wound bed in chronic wounds.

The two components work on different parts of the problem. The collagenase breaks down non-viable tissue, assisting wound bed preparation. The hyaluronic acid holds moisture at the wound site and helps protect newly formed tissue, since repair happens more readily in a moist environment.

The collagenase used in Hyalo4 START is 99% pure and derived from a non-pathogenic strain of Vibrio alginolyticus. Because it contains no non-specific protease, its action is confined to non-viable tissue and it does not irritate the skin surrounding the wound. The ointment is fluid and smooth, which makes application straightforward and comfortable for the patient.

Indications

Hyalo4 START is indicated for the local treatment of chronic wounds, including:

  • Pressure injuries
  • Vascular leg ulcers
  • Diabetic ulcers

How to use

  1. Clean and disinfect the wound before treatment.
  2. Ensure the wound bed is adequately moist. Dry lesions should be moistened with saline or another well tolerated solution. Hard eschar should be softened first with a suitable dressing.
  3. Apply an even layer of ointment across the wound bed.
  4. Cover with a secondary dressing.
  5. Repeat as directed by the treating clinician.

Specifications

Brand Hyalo4
Manufacturer Fidia Farmaceutici S.p.A., Italy
Active ingredients Hyaluronic acid sodium salt, bacterial collagenase
Collagenase source Non-pathogenic Vibrio alginolyticus, 99% pure
Format Fluid ointment, tube
Size 30g
Classification Medical device for topical use
Application Topical, direct to wound bed
Storage Store below 25°C. Do not freeze.

Frequently asked questions

Where does START sit in the Hyalo4 range?

START is used at the beginning of treatment, when the wound bed needs preparing. Hyalo4 SKIN contains hyaluronic acid alone and supports repair once the bed is clean. Hyalo4 CONTROL adds silver sulfadiazine for wounds that are infected or at risk of infection.

What does the collagenase actually do?

It breaks down non-viable tissue enzymatically, which assists wound bed preparation without the sharp debridement alternative. Because the enzyme is 99% pure with no non-specific protease, its action is limited to non-viable tissue and healthy surrounding skin is left alone.

Does the wound need to be moist before applying?

Yes. Collagenase needs moisture to work. Dry lesions should be moistened with saline or another well tolerated solution first, and hard eschar softened with a suitable dressing.

Can it be used under a dressing?

Yes, and a secondary dressing is normally applied over it to maintain the moist environment.

Will it irritate the skin around the wound?

The purity of the enzyme means there is no non-specific protease activity, which is the usual cause of dermatitis around the wound margin with enzymatic preparations.

Always read the label and use as directed. Use under the guidance of a healthcare professional. If symptoms persist or worsen, seek clinical advice.